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Polymorphism of the Vitamin D Receptor (VDR) Gene and a Suicide

Keywords:

L.A. Piruzjan, I.S. Nikolaeva, K.S. Gjulazizova, A.S. Kabankin, A.V. Sintsov, D.A. Radkevich, L.A. Radkevich


Suicide is widespread in the world. Researches show that the suicide is often happened because of depression. However taking energizers also can promote occurrence of suicide motivations. The status of vitamin D and polymorphism of the vitamin D receptor (VDR) gene (the chromosome 12q13.11) were investigated for many multifactorial diseases such as cancers , depressions, an osteoporosis, a diabetes, diseases of cardiovascular system (artery calcification), an asthma, myopia etc. As a rule, authors revealed participation of polymorphic alleles of VDR gene in pathological processes. In the present paper geographical distribution of a suicide in the world (60 populations) and association of mortality rates from a suicide with polymorphism of the vitamin D receptor gene (25-60 populations) have been investigated. It is established that mortality rates (MR – the numbers of deaths per 100 000 persons) from a suicide of men and women change in the following sequence: in Europe - 40, in northern America - 25, in Asia - 20, Southern America - 15, in Africa and Ocenia - 11. MRs from a suicide of men and women during 1980 - 2006 tend to decrease, both in the world, and in Russia. In Russia, Belarus and Estonia MRs from a suicide are the highest in the world. MRs from a suicide of men and women in the range of geographical latitudes from 0º to 33º are in 3-4 times more low, than in a range 34-65º. Significant moderate and salient by Chaddock scale direct correlations of MRs from a suicide of men and women with alleles of the VDR gene (rs11574026 T and rs2239182 G) have been established. Significant moderate and salient negative correlations of MRs from a suicide of men and women with alleles of the VDR gene (BsmI rs1544410 b intron A, ApaI rs11168271 intron 8 G a, TaqI rs731236 t exon 9 C, Cdx-2 rs11568820 promotor A, rs4760648 intron T, rs4237855 intron G) have been established. For men significant negative correlation is observed in 15-64 years (r = 0,5–0,7; p <0,001), for women - in 25-74 years (r =0,5 – 0,7; p <0,001). In last two age groups of men and women (65-74 and 75 + years) negative association of MR from a suicide is on the average (r = 0,4-0,5; p <0,02). Allele intron BsmI rs1544410 b-A for men and allele exon FokI rs2228570 f-T for men and women are not associated significantly with MR from a suicide. The conclusion: the analysis of geography of a suicide for 25-60 world countries was carried out, continents of high (Europe) and low (Ocenia) mortality rate from a suicide have been revealed. Dynamics of a suicide from 1980 for 2006 was investigated, testifying to the outlined decrease in mortality rate from a suicide in the world and in Russia. Dependence of a suicide on geographical latitude was established. The correlation analysis of association of MR from a suicide and alleles of the VDR gene has allowed to reveal alleles of risk of a suicide in men and women (rs11574026 T and rs2239182 G) and alleles of resistance to a suicide ( BsmI rs1544410 b-G in women, and ApaI rs7975232 a-G, TaqI rs731236 t-C, Cdx-2 rs11568820 1e-G, rs4760648 T, rs4237855 G in men and women). The received results may give evidence of association of mortality rate from a suicide with circadian rhythms, seasonal prevalence, intensity of an ultraviolet and the vitamin D maintenance in an organism
References:
May 29, 2020

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