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Combination of high-dose brachytherapy and external beam radiotherapy in the treatment of prostate cancer at high risk of progression


A. Pavlov, A. Tsybulsky, I. Albitskiy, S. Garmash, A. Gerasimov, T. Isaev, D. Blinov

Evaluate the preliminary results of combined radiation therapy with high dose rate source (Ir-192) in the treatment of prostate cancer patients at high risk of progression. From 2008 to 2010, 75 patients with a diagnosis of «prostate cancer» (PC) on combined treatment that included a high-dose brachytherapy Ir-192, followed by external beam radiation therapy (EBRT). All patients are at high risk of progression of the underlying disease. During brachytherapy (BT), all patients received a single fraction of 10 Gy. The average value of the total dose was 44-46 Gy EBRT, 2 Gy per fraction. All patients who participated in the study, conducted hormonal therapy for at least three months before the start of radiotherapy. The mean duration of follow-up period for the entire group was 31.6 months. Indicator 3-year disease-free survival rate was 93.3%. The frequency of late radiation complications III degree (on a scale of RTOG) were as follows: lower urinary tract 5%. Complications IV degree was observed. High-dose brachytherapy as boost combined with EBRT shows excellent clinical results, high rates of biochemical disease-free survival while maintaining quality of life at a high level.
May 29, 2020

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