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Influence of heteropoly acids with Keggin structure on influenza А viruses

Keywords:

O.A. Lopatina - Ph.D. (Med.), Leading Research Scientist, Tissue Culture Laboratory, Federal Reseach Center N.F. Gamaley of Epidemiology and Microbiology D.I. Ivanovsky Institute of Virology of Ministry of Health of the Russian Federation, Moscow. E-mail: cells@rambler.ru E.I. Isaeva - Ph.D. (Biol.), Leading Research Scientist, Laboratory of Immunology, Federal Reseach Center N.F. Gamaley of Epidemiology and Microbiology D.I. Ivanovsky Institute of Virology of Ministry of Health of the Russian Federation, Moscow. E-mail: immunol.lab@mail.ru I.A. Suetina - Ph.D. (Biol.), Leading Research Scientist, Tissue Culture Laboratory, Federal Reseach Center N.F. Gamaley of Epidemiology and Microbiology D.I. Ivanovsky Institute of Virology of Ministry of Health of the Russian Federation, Moscow. E-mail: cells@rambler.ru O.V. Baklanova - Ph.D. (Biol.), Chief Research Scientist, Tissue Culture Laboratory, Federal Reseach Center N.F. Gamaley of Epidemiology and Microbiology D.I. Ivanovsky Institute of Virology of Ministry of Health of the Russian Federation, Moscow. E-mail: cells@rambler.ru L.I. Russu - Research Scientist, Tissue Culture Laboratory, Federal Reseach Center N.F. Gamaley of Epidemiology and Microbiology D.I. Ivanovsky Institute of Virology of Ministry of Health of the Russian Federation, Moscow. E-mail:cells@rambler.ru T.N. Pritchina - Research Scientist, Tissue Culture Laboratory, Federal Reseach Center N.F. Gamaley of Epidemiology and Microbiology D.I. Ivanovsky Institute of Virology of Ministry of Health of the Russian Federation, Moscow. E-mail: cells@rambler.ru S.A. Kovalevskii - Dr.Sc. (Phys.-Math.), Laboratory of Chemical Physics of Nanostructures, Institute of Chemical Physics n.a. N.N. Semenov of Russian Academy of Sciences, Moscow. E-mail: icp@chph.ras.ru F.I. Dalidchik - Dr.Sc. (Phys.-Math.), Professor, Head of Laboratory of Theoretical Problems of Chemical Nanophysics, Institute of Chemical Physics n.a. N.N. Semenov of Russian Academy of Sciences, Moscow. E-mail: gomfgal@mail.ru M.V. Mezentseva - Dr.Sc. (Biol.), Head of Tissue Culture Laboratory, Federal Reseach Center N.F. Gamaley of Epidemiology and Microbiology D.I. Ivanovsky Institute of Virology, Ministry of health of the Russian Federation, Moscow. E-mail: marmez@mail.ru


Influenza viruses are the most common among acute respiratory viral infections. High incidence of the disease at seasonal pickup and epidemies, a high percentage of complications, virus variety, rapid drug resistance appearance induce to generate new antiviral agents. POMs could be perspective in this point and could be used in antiviral drug formula. Antiviral effects of POMs are studied extensively nowadays. Among large amount of different POMs, heteropoly acids with Keggin structure are the most chemically investigated POM. Keggin polyoxometalates were investigated in this work. Keggin POM’s influence on hemagglutinating and infectious activity of different influenza strains (influenza А/Aichi/1/68(Н3N2), А/California/07/09/(Н1N1) и А/Pert16/09(Н3N2)) was investigated. The most virucidal effect on investigated strains was observed after exposure of Keggin POMs with H4SiW12O40 and H4SiMo12O40. POMs effect on cytokines synthesis was investigated. A wide spectrum of cytokine mRNA activities after POM exposure was examined in cells culture HEF. It was demonstrated that, Keggin’s heteropoly acids activated gene transcription of INF-γ, IL-18, IL-1β, IL-8, TNF-α, which played an important role in antiviral immunity. As a result, cytokines in vivo promote macrophage and cellular components of immune system and play an important role in infectious diseases. Investigation of POMs action mechanism could promote the development of drugs, based on POM.
References:

 

  1. Pope M.T. Heteropoly Oxometalates. Berlin: Springer-Verlag. 1983.
  2. Rhule J.T., HillC. L., Judd D.A., et. al. Polyoxometalates in medicine // Chem. Rev. 1998. V. 98. P. 327-358.
  3. Shigeta S., Mori S., Watanabe J., Baba M., Khenkin A.M., Hill C.L., Schinazi R.F. In vitro antimyxovirus and anti-human immunodeficiency virus activities of polyoxometalates // Antivir. Chem. Chemother. 1995. № 6. R. 114–122.
  4. Rhule J.T., Hill C.L., Judd D.A., Schinazi R.F. Polyoxometalates in medicine // Chem. Rev. 1998. V. 98. P. 327-358.
  5. Raynaud M., Chermann J.C., Plata F., Jasmin C., Mathe G.C.R. // Acad. Sci. Ser. D. 1971. R. 272, 347.
  6. Wang J., Liu Y., Xu K., Qi Y., Zhong J., Zhang K., Li J., Wang E., Wu Z., Kang Z. Broad-Spectrum Antiviral Property of Polyoxometalate Localized on a Cell Surface // ACS Appl. Mater. Interfaces. 2014. № 6. R. 9785-9789.
  7. Shigeta S., Mori S., Yamase T., Yamamoto T. Anti-RNA virus activity of polyoxometalates // Biomed. Pharmacother. 2006. V. 60. P. 211-219.
  8. Hosseini S.M., Amini E., Kheiri M.T., Mehrbod P., Shahidi M., Zabihi M. Anti-influenza Activity of a Novel Polyoxometalate Derivative (POM-4960) // Int. J. Mol. Cell. Med. Winter 2012. V. 1. № 1. P. 21-29.
  9. Lopatina O.A., Baklanova O.V., Suetina I.A., Isaeva E.I., Gushhina E.A., Russu L.V., Lisicin F.A., Kovalevskijj S.A., Budanov B.A., Dalichik F.I., Mezenceva M.V. Citotoksicheskoe i protivovirusnoe dejjstvie polioksometallatov v opytakh in vitro // Sb. materialov KHKH11 Ross. nacion. kongressa «CHelovek i lekarstvo». M. 2015. 230 s.
  10. Lopatina O.A., Baklanova O.V., Suetina I.A., Isaeva E.I., Gushhina E.A., Russu L.V., Lisicin F.A., Kovalevskijj S.A., Budanov B.A., Dalichik F.I., Mezenceva M.V. Issledovanie toksicheskogo ehffekta polioksometallatov so strukturojj Keggina na kultury normalnykh i onkogennykh kletok // Biologicheskaja radioehlektronika. 2015. № 3. S. 42-49.
  11. KHabriev R.U. Rukovodstvo po ehksperimentalnomu (doklinicheskomu) izucheniju novykh farmakologicheskikh veshhestv. M.: Medicina. 2005. 832 s.
  12. Kuzovkova N.A., Samojjlovich L.D., Makovskaja L.D. Ocenka proliferativnojj aktivnosti limfocitov v MTT-teste (instrukcija po primeneniju. Utverzhdena i vvedena v dejjstvie Ministerstvom zdravookhranenija Respubliki Belarus. Registracionnyjj №40-0201 ot 09.04. 2002 g.)
  13. Suetina I.A., Podchernjaeva R.JA., Gushhina E.A., Lopatina O.A., Poklonov V.A., Ostroumov S.A. Ispolzovanie kletochnykh tekhnologijj dlja ocenki toksichnosti nanochastic okislov metallov // Materialy mezhdunar. nauchno-praktich. konf. «Farmacevticheskie i medicinskie biotekhnologii» (20-22 marta 2013 g., Moskva). M.: EHkspo-biokhim-tekhnologii, RKHGU im. D.I. Mendeleeva. S. 134-135.
  14. Suetina I.A., Mezenceva M.V., Gushhina E.A., Lisicin F.A., Russu L.I., Lopatina O.A., Firsova E.L., Kovalevskijj S.A., Budanov.B.A., Dalidchik F.I., Seleznev A.S., Morozov R.A. Izuchenie rostovojj aktivnosti i zhiznesposobnosti kultiviruemykh fibroblastov ehmbriona cheloveka pod vozdejjstviem polioksometallatov // Kletochnye kultury informacionnyjj bjulleten. 2015. Vyp. 31. S. 67-79.
  15. Chomezynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinum thyocyoanate-phenol-chloroform extraction // Anal. Biochem. 1987. V. 162. R. 156-159.
  16. Gelder C.M., Thomas P.S., Yates D.H., Adcock I.M., Morrison J.F.J., Barnes P. Cytokine expression in normal, atopic and asthmatic subject using the combination of sputum induction and the polymerase chain reaction // Thorax. 1995. V. 50. P. 1033-1037.
  17. Lin Y., Zhang M., Barnes P.F.Chemokine production by human alveolar epithelial cell line in response by Mycobacterium tuberculosis // Infection and Immunity. 1998. V.66. № 3. P. 1121-1126.
  18. Berry J.P., Galle P. Subcellular Localization of HPA-23 in Different Rat Organs: Electron Microprobe Study // Exp. Mol. Pathol. 1990. № 53. R. 255−264.
  19. Zhang H., Qi, Y.F., Ding Y.H., Wang J., Li Q.M., Zhang J.Z., Jiang Y.F., Chi X.M., Li J., Niu J.Q. Synthesis, Characterization and Biological Activity of a Niobium-Substituted Heteropolytungstate on Hepatitis B Virus // Bioorg. Med. Chem. Lett. 2012. № 22. R. 1664−1669.
  20. Shigeta S., Mori S., Kodama E., Kodama J., Takahashi K., Yamase T. Broad Spectrum Anti-RNA Virus Activities of Titanium and Vanadium Substituted Polyoxotungstates // Antiviral Res. 2003. № 58. R. 265−271.

 

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