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Matrix metalloproteinases and their tissue inhibitors in normal and tumors of the kidney


O.I. Kostyleva - Ph.D. (Med.), Senior Research Scientist, Clinical Biochemistry Laboratory, N.N. Blokhin Russian Cancer Research Center, Moscow E-mail: V.V. Mushtenko - Post-graduate Student, Clinical Biochemistry Laboratory, N.N. Blokhin Russian Cancer Research Center, Moscow S.D. Bezanova - Post-graduate Student, Pathology Department, N.N. Blokhin Russian Cancer Research Center, Moscow D.S. Mikhaylenko -Ph.D. (Med.), Senior Research Scientist, Institute of Molecular Medicine, Sechenov First Mos-cow State Medical University Senior Researcher Russia, Moscow N.E. Kushlinskii - Dr.Sc. (Med.), Professor, Member-Correspondent of Russian Academy of Sciences, Head of the Clinical Biochemistry Laboratory, N.N. Blokhin Russian Cancer Research Center, Moscow

A review of the literature is devoted to the role of the system of matrix metalloproteinases and their tissue inhibitors in renal pathology and, in particular, in renal carcinoma. Due to the absence of screening, diagnostic models for early diagnosis, as well as specific monitoring of relapse for renal tumors, the urgent task is the identification of new biomarkers of renal tumor. Recent studies demonstrate the prospects of using the system MMP/TIMP not only as a diagnostic but also a prognostic markers in some renal tumors, as well as to assess the effectiveness of targeting anticancer therapy.



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