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Influence of passive smoking on the element homeostasis in the mother-placenta-fetus system

DOI 10.18127/j20700997-201902-04

Keywords:

S.V. Notova –
Dr.Sc. (Med.), Professor, First Deputy Director, Federal Research Center for Biological Systems and Agrotechnologies of RAS (Orenburg)
E-mail: snotova@mail.ru
L.V. Lizyrchik –
Gynecologist, Regional Clinical Hospital №2 Perinatal Centre (Orenburg); Research Scientist of Federal Research Center for Biological Systems and Agrotechnologies of RAS (Orenburg)
E-mail: lizurchik@mail.ru
O.V. Marshinskaya –
Junior Research Scientist, Federal Research Center for Biological Systems and Agrotechnologies of RAS (Orenburg)
E-mail: m.olja2013@yandex.ru
T.V. Kazakova –
Junior Research Scientist, Federal Research Center for Biological Systems and Agrotechnologies of RAS
E-mail: vaisvais13@mail.ru


Tobacco smoking is one of the most common habits in the world which harms people's health and society in general. Aimed: study the content of bioelements in the body of pregnant rats and their fetuses as a result of passive smoking. Methods. The study was conducted in the reproductive female Wistar rats (n=20). Animals were divided into two groups (control and expe-rimental groups). The control group was in the exposure chamber without tobacco smoke for 30 minutes 2 times a day. Animals of the experimental group were in the exposure chamber with tobacco smoke for 30 minutes 2 times a day. Pregnant rats were exposed in the following days. Every rat of the experimental group got 0.048 mg of nicotine, which is equivalent to the dose of the average smoker. The elemental composition of biological substrates (lung, liver, bone, placenta, fetus) was studied through the use of ICP-AES and ICP-MS. Results. Redistribution of chemical elements in the mother's body was found out. There was a statistically reliable decrease in the level of trace elements in the pulmonary tissue: chrome by 60 %, iodine by 35 %, cobalt by 36%, manganese by 50%; there was an increase in toxic elements such as arsenic by 37.5%, lead by 55% and cadmium by 46%. Copper and iron concentrations decreased by 7 % and 41.5 % in the liver tissue, respectively; there was an increase in strontium by 11.9 %. There was a decrease in the amount of nickel by 59 %, zinc by 45 %, silicon by 25.8 % and an increase in tin, aluminum, lead by 69.1 %, 42.6 %, 31.5 %, respectively, in the bone tissue. There was an increase in cadmium by 79.8 % and lead by 38.7 % in the placental samples of female rats. There was registered active accumulation of a number of chemical elements: manganese by 11.2 %, zinc by 15 %, selenium by 34.2 %, vanadium by 64%, boron by 54%, chromium by 75 %, iodine by 78.8 %, aluminum by 54%, cadmium by 77% and lead by 88.1 % in the body of the fetus. Conclusions. By summing the results, it is assumed a significant negative impact of passive smoking on the metabolism of trace elements and toxic elements in the mother-placenta-fetus system.

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June 24, 2020
May 29, 2020

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