Ya. A. Kainov, I.B. Zborovskaya
Retinoic acid promotes differentiation of various cell types. Retinoic acid and its derivates regulate a wide range of biological processes including development, proliferation, angiogenesis and apoptosis. Genetic disorders that lead to a decrease in cell sensitivity to retinoic acid are widely distributed in various human tumors and probably functionally related to the process of carcinogenesis.
CRABPI (Сellular retinoic acid binding protein I) localizes in cytoplasm and mediates cellular response to retinoic acid. Despite the fact that its intracellular function is not fully understood, most data indicates the active role of this protein in enhancing the metabolism of retinoic acid. CRABPI plays a key role in retinoid resistance formation in acute promyelocytic leukemia patients with RARα–PLZF translocation.
Changes in the expression of CRABPI are detected in different human solid tumors such as lung adenocarcinoma, ovarian adenocarcinoma, esophageal adenocarcinoma, different brain tumors etc., but mechanisms of its participation in tumor progression are still unknown. This review presents the currently known data on the participation of this protein in carcinogenesis.